- DNA Methylation
- DNA Methylation
- DNA Methyltransferase
- Epigenetic Code
- Methylation
- Methyl Group
- Epigenetics
- CpG Islands
- DNA Methylation Links
- DNA Methylation Analysis
- DNA Methylation and Cancer
- DNA Methylation PCR
- DNA Methylation Kits
- Molecular Biology
- Methylation Directory
- Bioinformatics
- Demethylating Treatment
- TSA Treatment
- MS-PCR
- ChIP
Epigenetic Code
Epigenetic Code
The Epigenetic Code is found in eukaryotic cells and consists of regulating the expression of the genetic code through DNA methylation and the histone code.
Histone Code
The histone code is part of the epigenetic code and consists of modifying histone tails, with modifications such as methylation, acetylation, ubiquitination, phosphorylation and ADP-ribosylation. These modifications guide the chromatin-DNA interaction and thereby cause changes in the configuration of the DNA to be accessibily to transcription factors or not.
Histones generally bind to DNA to form nucleosomes, which together form chromatin. Histones are proteins with a N-terminus that extends from the nucleosome and is readily accessible to modifications, thereby playing an important role for controlling DNA-protein interactions, and chromatin structure.
Histone Code Alterations
Chromosomal condensation occurs when there is phosphorylation of histone H3 serine residues 10 and 28. Histone H3 phosphorylation of serine 10 plus acetylation of histone H3 lysine residue 14 allows for transcription to occur.
DNA Methylation
DNA methylation is a process of modifying DNA to alter gene expression, as well as chromatin packaging. Read more from the links to the left and above to learn more about this fascinating modification to DNA, DNA Methylation.
